EML OPIOIDS FOR CANCER PAIN: A COMPARATIVE OVERVIEW General Index

METHADONE 17 Introduction 17 Pharmacology of methadone 17 Chemical characteristics 17 Pharmacodynamics 17 Pharmacokinetics 18 Drug interactions 19 References 22 Efficacy of Methadone in Clinical Studies 24 Figure 1. Consort – like report of Eligible Papers. 25 Summary of data for Efficacy (Table 1, Appendix 1). 26 Search Method 26 Systematic Review (Table 3, Appendix 1). 28 Retrospective Studies (Table 4, Appendix 1). 30 Prospective Open Label studies; Observational studies (Table 5, Appendix 1). 31 Case Report; Case Series (Table 6, Appendix 1). 32 References 33 Toxicities of Methadone in Clinical Studies 37 Figure 1. Search for Toxicity. 37 Summary of data for Toxicity (Table 1, Appendix 2). 38 Search Method 38 Review (Table 2, Appendix 2). 39 Retrospective Studies (Table 3, Appendix 2). 40 Observational Studies (Table 4, Appendix 2). 41 Case Reports/Case Series (Table 5, Appendix 2). 42 References 43 Clinical considerations on Methadone 44 References 45